Cell Death, Inflammation and Cancer
II International Conference on Molecular Biology
November 2-3, 2016, St Petersburg, SPSIT (TU)

The St. Petersburg State Institute of Technology (Technical University) invites you to take part in the II International conference "Cell Death, Inflammation and Cancer" which will take place on November 2-3, 2016. Organizers of conference are SPSIT (TU) and Cellular Biotechnology laboratory with support of the Ministry of Education and Science of the Russian Federation.

Conference is held within the Resolution No. 220 of the Government of the Russian Federation under the leadership of the leading scientist Martin Seamus.

The leading scientists take part in conference in the field of molecular biology and immunology from Russia, Austria, Ireland, Portugal and Belgium.

The beginning 1100

 

Within the conference there will be observed following issues:

  • Tumor cell death
  • The p53 family in cancer biology
  • Use of C. Elegans as a model organism for the study of human diseases
  • Inflammatory Signaling, Autophagy and Dying Cell Clearance
  • Cell death by inhibition of glucose metabolism
  • Processing and activation of IL-1 family cytokines
 

 

SPEAKERS

Andreas Villunger

Andreas Villunger

Innsbruck Medical University, Austria

Andreas Villunger received his PhD at the University of Innsbruck, Austria, in 1996 where was working at the hemato-oncology department on cytokine signaling in multiple myeloma. After a first postdoc exploring the role of novel Protein kinase C proteins in transformation and immune cell signaling he moved to the Walter and Eliza Hall Institute in Melbourne, Australia, where he performed postdoctoral studies in the field of BCL2 regulated cell death, lymphocyte development and transformation. He established a number of BH3-only protein knock-out mouse mutants thereby establishing the network responsible for p53-mediated cell death. After his return to Austria he became professor at the Medical University Innsbruck where he is now heading the Division of Developmental Immunology investigating cell death and cell cycle cross talks in the context of cancer therapeutics and mechanisms connecting the cell cycle machinery with the p53 network and lymphocyte maturation.

Seamus Martin

Seamus Martin

Trinity College, Dublin, Ireland

Seamus Martin is the holder of the Smurfit Chair of Medical Genetics at Trinity College Dublin (since 1999). He has an international reputation in the field of programmed cell death (apoptosis), which is highly relevant to cancer and immunity to infectious agents, and is one of the most highly cited scientists in the world on this topic.


 

Colin Adrian

Colin Adrian

The Gulbenkian Institute of Sciences (IGC), Portugal

Colin Adrain received his PhD from Trinity College Dublin in 2003 where he studied the molecular regulation of apoptosis under the mentorship of Prof. Seamus Martin. He then moved to the MRC Laboratory of Molecular Biology (LMB) in Cambridge, UK, where he was a postdoctoral fellow under the mentorship of Prof. Matthew Freeman. In Cambridge, he studied the molecular and physiological role of rhomboid like proteins, discovering that iRhoms, catalytically inactive rhomboid-like proteins, are essential for activation of TACE, the protease responsible for release for the inflammatory cytokine TNF (Tumor Necrosis Factor) from immune cells. Since June 2013, Dr Adrain has been a PI at the Gulbenkian Institute (IGC) in Lisbon, Portugal. At IGC, his lab focuses on the control of signaling by secretory trafficking in cellular and mouse models.

Danielle Clancy

Danielle Clancy

Deptment of Genetics, Trinity College Dublin, Ireland

Danielle Clancy has recently submitted her PhD thesis under the supervision of Prof. Seamus Martin in the Molecular Cell Biology Laboratory in the Smurfit Institute of Genetics, Trinity College Dublin.  She received her Bachelor’s degree in Biotechnology from Dublin City University in 2011.  Her work focuses on the immunomodulatory role of neutrophils in the regulation of the activity states of IL-1 family cytokines.  These immune cells can promote and potentiate inflammation by regulating the activity of multiple IL-1 family members, which may play an important role in infection, inflammatory diseases and cancer.


 

Peter Vandenabeele

Peter Vandenabeele

The VIB, University of Ghent, Belgium

The research unit of Peter Vandenabeele focuses on the molecular mechanisms of different cell death modalities (a.o. apoptosis, necroptosis, ferroptosis, immunogenic cell death) and cellular stress (ER stress), their regulation, their functional interactions and the role herein of caspases, RIPK and other signalling molecules. The unit is both interested in cell autonomous as well as intercellular aspects of cell death and cellular stress such as communication with the innate immune system. These processes are studied in an integrated way at the level of biochemistry, cell biology, development of conditional transgenic models and their role in various diseases models such as sepsis, skin inflammation and cancer, and intestinal inflammation and cancer. In order to identify novel targets in signalling of cell death modalities we developed a cellular screening platform in which we screen customized functional classes of libraries of sh/siRNAs (kinases, ubiquitylating enzymes, etc.), libraries of known clinical drugs and series of chemical compounds. The hits are then further examined in cellular systems and in experimental disease models for their potential to modulate cell death pathways or to influence disease models.

Graeme Sullivan

Graeme Sullivan

Trinity College Dublin, Ireland

Graeme Sullivan is a graduate of Trinity College Dublin, where he received his Bachelor’s degree in Dental Science. Since 2012, he has worked under the supervision of Professor Seamus Martin in the Molecular Cell Biology Laboratory, Smurfit Institute, Trinity College Dublin examining the interplay between cell death, inflammation and cancer. His current work focuses on the identification and development of novel peptide-based therapeutics aimed at inhibiting IL-36 proteolytic processing by neutrophil-derived proteases in the context of skin inflammatory disease.


 

Pavel Davidovich

Pavel Davidovich

The VIB, University of Ghent, Belgium

Pavel Davidovich received his master degree in Molecular Biotechnology in the Saint-Petersburg State Technological Institute and Ph.D. degree in the area of bioinorganic chemistry of nitric oxide donors. From 2011 until 2013 he was working in drug design field developing molecules that stabilize p53 family proteins. From 2013 working in prof. Martins laboratory, he has focused on protease inhibitors design. His professional interests lie in the field of molecular aspects of inflammation in cancer and bioinorganic chemistry.

Alexander Garabadzhiu

Alexander Garabadzhiu

St Petersburg State Institute of Technology, St. Petersburg, Russia

Professor Alexander Garabadzhiu is the Vice-rector for scientific work at the St. Petersburg State Institute of Technology (Technical University). Alexander Garabadzhiu is the known expert in the field of biochemistry for developing medical diagnostic systems. His research area includes toxicity and pathogenic microorganisms. He has developed technological techniques, such as a new class of DNA fluorescent probes, and has worked on retinoids analogous to vitamin A, in which he developed "Adapalen".

PROGRAM

Tuesday Nov 1st 2016

Arrival and welcome gathering

Wednesday Nov 2nd

Auditorium № 15, Department of Systems Analysis

11:00–11:15

Alexandr Garabadzhiu and Seamus Martin

Welcome and Introduction

11:15–12:00

Peter Vandenabeele, VIB, Ghent

Necroptosis and inflammation: where are we, where are we going?

12:00–12:30

Danielle Clancy, Trinity College Dublin

Regulation of IL-1 family cytokine activation states by neutrophil-derived proteases

12:30–1:00

Round table on Key issues in Cell death, Inflammation and Cancer research, Chaired by Seamus Martin

1:00–2:30pm

Lunch

2:30–3:15

Andreas Villunger, Innsbruck Medical University

Regulation of cell death in mitosis

3:15–3:45

Graeme Sullivan, Trinity College Dublin

Identification of peptide-based antagonists of IL-36 cytokine processing enzymes, key drivers of inflammation

3:45–4:15

Coffee

4:15–5:00

Seamus Martin, Saint Petersburg State Institute of Technology and Trinity College

Cell Death and Inflammation

5:00–5:30

Visit to the Mendeleyev Museum

8:00pm

Dinner

Thursday November 3rd

Laboratory of Molecular Pharmacology

10:30–10:45

Colin Adrian, IGC, Lisbon

Rhomboid proteases and inflammation

10:45–11:15

Pavel Davidovich, Saint Petersburg State University

Identification of small molecule antagonists of neutrophilderived proteases using in silico docking

11:15–11:45

Coffee

11:45–1:00

General discussion on Collaborative opportunities and bottleknecks in the Cell Death and Inflammation fields, Chaired by Andreas Villunger

1:00–2:30

Lunch

2:30–4:30

Workshop on How to publish in the Life Sciences

Seamus Martin, Editor-in-chief, The FEBS Journal

Peter Vandenabeele, Editorial Board Member, Cell Death and Differentiation

Andreas Villunger, Editorial Board Member, Cell Death and Differentiation

Colin Adrian, Viewpoints Editor, The FEBS Journal

4:30–6:30

Bus tour of the historical center of Saint Petersburg

8:00pm

Dinner

 

ФОТОАРХИВ МЕРОПРИЯТИЯ